Exercise oncology. From theory to the practice

Soraya Casla-Barrio, Jordi Alfaro-Gamero

Abstract


Exercise-Oncology is an emerging area with a lot of questions for physical activity professionals focused on health. This review collects the general side effects and exercise implication and benefits, such as body composition changes, cardiovascular limitations or functional impairments as lymphedema; exercise relevance in cancer biomarkers related to cancer prognosis; as well as the exercise cautions related to some specific side effects. In addition, exercise recommendations to specialists are explained, including practice suggestions about how to personalize exercise prescription collecting a clinical history in order to control patient’s development; how to control exercise intensity with different devices; and, finally, types of exercise and how they should be developed in terms of intensity and volume.

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Arena, R., Myers, J., Forman, D. E., Lavie, C. J., & Guazzi, M. (2013). Should high-intensity-aerobic interval training become the clinical standard in heart failure?. Heart Failure Reviews, 18(1), 95-105. doi:10.1007/s10741-012-9333-z.

Balady, G. J., Berra, K. A., Golding, L. A., Gordon, N. F., Mahler, D. A., Myers, J. N., & Sheldahl, L. M. (2000). ACSM's Guidelines for exercise testing and prescription. Sixth Edition (E. P. Johnson Ed.). Baltimore: Lippincott Williams & Wilkins.

Berger, A. M., Gerber, L. H., & Mayer, D. K. (2012). Cancer-related fatigue: implications for breast cancer survivors. Cancer, 118(8 Suppl), 2261-2269. doi:10.1002/cncr.27475.

Braithwaite, D., Satariano, W. A., Sternfeld, B., Hiatt, R. A., Ganz, P. A., Kerlikowske, K., . . . & Caan, B. J. (2010). Long-term prognostic role of functional limitations among women with breast cancer. Journal of the National Cancer Institute, 102(19), 1468-1477. doi:10.1093/jnci/djq344.

Cabanes, A., Vidal, E., Aragones, N., Perez-Gomez, B., Pollan, M., Lope, V., & Lopez-Abente, G. (2010). Cancer mortality trends in Spain: 1980-2007. Annals of oncology, 21(Suppl 3), 14-20. doi:10.1093/annonc/mdq089.

Chen, X., Lu, W., Zheng, W., Gu, K., Matthews, C. E., Chen, Z., . . . & Shu, X. O. (2011). Exercise after diagnosis of breast cancer in association with survival. Cancer Prevention Research, 4(9), 1409-1418. doi:10.1158/1940-6207.CAPR-10-0355.

Cody, J. D., Jacobs, M. L., Richardson, K., Moehrer, B., & Hextall, A. (2012). Oestrogen therapy for urinary incontinence in post-menopausal women. Cochrane Database Systematic Review, 10, CD001405. doi:10.1002/14651858.CD001405.pub3.

Coleman, R. E., Body, J. J., Gralow, J. R., & Lipton, A. (2008). Bone loss in patients with breast cancer receiving aromatase inhibitors and associated treatment strategies. Cancer Treatment Reviews, 34, 31-42. doi:10.1016/j.ctrv.2008.03.005.

Cormie, P., Pumpa, K., Galvao, D. A., Turner, E., Spry, N., Saunders, C., . . . & Newton, R. U. (2013). Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomised controlled trial. Journal of Cancer Survivorship, 7(3), 413-424. doi:10.1007/s11764-013-0284-8.

Courneya, K. S., Mackey, J. R., Bell, G. J., Jones, L. W., Field, C. J., & Fairey, A. S. (2003). Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. Journal of Clinical Oncology, 21(9), 1660-1668. doi:10.1200/JCO.2003.04.093.

Demark-Wahnefried, W., Case, L. D., Blackwell, K., Marcom, P. K., Kraus, W., Aziz, N., . . . & Shaw, E. (2008). Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clinical Breast Cancer, 8(1), 70-79. doi:10.3816/CBC.2008.n.005.

Demark-Wahnefried, W., Winer, E. P., & Rimer, B. K. (1993). Why women gain weight with adjuvant chemotherapy for breast cancer. Journal of Clinical Oncology, 11(7), 1418-1429. doi:10.1200/JCO.1993.11.7.1418.

Denlinger, C. S., Ligibel, J. A., Are, M., Baker, K. S., Demark-Wahnefried, W., Dizon, D., . . . & National comprehensive cancer (2014). Survivorship: healthy lifestyles, version 2.2014. Journal of the National Comprehensive Cancer Network, 12(9), 1222-1237.

Dickerson, S. S., Connors, L. M., Fayad, A., & Dean, G. E. (2014). Sleep-wake disturbances in cancer patients: narrative review of literature focusing on improving quality of life outcomes. Nature and Science of Sleep, 6, 85-100. doi:10.2147/NSS.S34846.

DiSipio, T., Rye, S., Newman, B., & Hayes, S. (2013). Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. The Lancet Oncology, 14(6), 500-515. doi:10.1016/S1470-2045(13)70076-7.

Fairey, A. S., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., & Mackey, J. R. (2003). Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. Cancer Epidemiology and Prevention Biomarkers, 12(8), 721-727.

Fairey, A. S., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., & Mackey, J. R. (2005). Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. Journal of Applied Physiology, 98(4), 1534-1540. doi:10.1152/japplphysiol.00566.2004.

Fairey, A. S., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., Martin, B. S., & Mackey, J. R. (2005). Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: a randomized controlled trial. Brain, Behavior, and Immunity, 19(5), 381-388. doi:10.1016/j.bbi.2005.04.001.

Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., Mathers, C., . . . & Bray, F. (2012). GLOBOCAN. From Lyon, France: International Agency for Research on Cancer.

Friedenreich, C. M., Neilson, H. K., Woolcott, C. G., Wang, Q., Stanczyk, F. Z., McTiernan, A., . . . & Courneya, K. S. (2012). Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal women. Cancer Prevention Research, 5(1), 98-108. doi:10.1158/1940-6207.CAPR-11-0369.

Friedenreich, C. M., Woolcott, C. G., McTiernan, A., Ballard-Barbash, R., Brant, R. F., Stanczyk, F. Z., . . . & Courneya, K. S. (2010). Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. Journal of Clinical Oncology, 28(9), 1458-1466. doi:10.1200/JCO.2009.24.9557.

Galanti, G., Stefani, L., & Gensini, G. (2013). Exercise as a prescription therapy for breast and colon cancer survivors. International Journal of General Medicine,, 6, 245-251. doi:10.2147/IJGM.S42720

Gaman, A. M., Uzoni, A., Popa-Wagner, A., Andrei, A., & Petcu, E. B. (2016). The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-"Chemobrain". Aging and Disease, 7(3), 307-317. doi:10.14336/AD.2015.1022.

Gibala, M. J., Little, J. P., Macdonald, M. J., & Hawley, J. A. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology, 590(5), 1077-1084. doi:10.1113/jphysiol.2011.224725.

Gil-Rey, E., Quevedo-Jerez, K., Maldonado-Martin, S., & Herrero-Roman, F. (2014). Exercise Intensity Guidelines for Cancer Survivors: a Comparison with Reference Values. International Journal of Sports Medicine, 35(14), e1-e9. doi:10.1055/s-0034-1389972.

Guru, K., Manoor, U. K., & Supe, S. S. (2012). A comprehensive review of head and neck cancer rehabilitation: physical therapy perspectives. Indian Journal of Palliative Care, 18(2), 87-97. doi:10.4103/0973-1075.100820.

Han, Y., Mao, F., Wu, Y., Fu, X., Zhu, X., Zhou, S., . . . & Zhao, Y. (2011). Prognostic role of C-reactive protein in breast cancer: a systematic review and meta-analysis. The International Journal of Biological Markers, 26(4), 209-215. doi:10.5301/JBM.2011.8872.

Hansen, D., Stevens, A., Eijnde, B. O., & Dendale, P. (2012). Endurance exercise intensity determination in the rehabilitation of coronary artery disease patients: a critical re-appraisal of current evidence. Sports Medicine, 42(1), 11-30. doi:10.2165/11595460-000000000-00000.

Hayes, S. C., Johansson, K., Stout, N. L., Prosnitz, R., Armer, J. M., Gabram, S., & Schmitz, K. H. (2012). Upper-body morbidity after breast cancer: incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of care. Cancer, 118(8 Suppl), 2237-2249. doi:10.1002/cncr.27467.

Heikkila, K., Ebrahim, S., & Lawlor, D. A. (2007). A systematic review of the association between circulating concentrations of C reactive protein and cancer. Journal of Epidemiology & Community Health, 61(9), 824-833. doi:10.1136/jech.2006.051292.

Herrero, F., San Juan, A. F., Fleck, S. J., Foster, C., & Lucia, A. (2007). Effects of detraining on the functional capacity of previously trained breast cancer survivors. International Journal of Sports Medicine, 28(3), 257-264. doi:10.1055/s-2006-924348.

Holmes, M. D., Chen, W. Y., Feskanich, D., Kroenke, C. H., & Colditz, G. A. (2005). Physical activity and survival after breast cancer diagnosis. JAMA, 293(20), 2479-2486. doi:10.1001/jama.293.20.2479.

Humpel, N., & Iverson, D. C. (2007). Depression and quality of life in cancer survivors: is there a relationship with physical activity? International Journal of Behavioral Nutrition and Physical Activity, 4, 65. doi:10.1186/1479-5868-4-65.

Institute, N. C. http://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf.

Irwin, M. L. (2009). Physical activity interventions for cancer survivors. British Journal of Sports Medicine, 43(1), 32-38. doi:10.1136/bjsm.2008.053843.

Irwin, M. L., McTiernan, A., Manson, J. E., Thomson, C. A., Sternfeld, B., Stefanick, M. L., . . . & Chlebowski, R. (2011). Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative. Cancer Prevention Research, 4(4), 522-529. doi:10.1158/1940-6207.CAPR-10-0295.

Jones, L. W., & Courneya, K. S. (2002). Exercise counseling and programming preferences of cancer survivors. Cancer Practice, 10(4), 208-215.

Jones, L. W., Eves, N. D., Peddle, C. J., Courneya, K. S., Haykowsky, M., Kumar, V., . . . & Reiman, T. (2009). Effects of presurgical exercise training on systemic inflammatory markers among patients with malignant lung lesions. Applied Physiology, Nutrition, and Metabolism, 34(2), 197-202. doi:10.1139/H08-104.

Kessler, H. S., Sisson, S. B., & Short, K. R. (2012). The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Medicine, 42(6), 489-509. doi:10.2165/11630910-000000000-00000.

Kilgour, R. D., Vigano, A., Trutschnigg, B., Hornby, L., Lucar, E., Bacon, S. L., & Morais, J. A. (2010). Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer. Journal Cachexia Sarcopenia Muscle, 1(2), 177-185. doi:10.1007/s13539-010-0016-0.

Kim, C. J., Kang, D. H., Smith, B. A., & Landers, K. A. (2006). Cardiopulmonary responses and adherence to exercise in women newly diagnosed with breast cancer undergoing adjuvant therapy. Cancer Nursing, 29(2), 156-165.

Kim do, S., Sim, Y. J., Jeong, H. J., & Kim, G. C. (2010). Effect of active resistive exercise on breast cancer-related lymphedema: a randomized controlled trial. Archives of Physical Medicine and Rehabilitation, 91(12), 1844-1848. doi:10.1016/j.apmr.2010.09.008.

Kumar, M., Nagpal, R., Hemalatha, R., Verma, V., Kumar, A., Singh, S., . . . & Yadav, H. (2012). Targeted cancer therapies: the future of cancer treatment. Acta Bio Medica Atenei Parmensis, 83(3), 220-233.

Kumar, N. B., Riccardi, D., Cantor, A., Dalton, K., & Allen, K. (2005). A case-control study evaluating the association of purposeful physical activity, body fat distribution, and steroid hormones on premenopausal breast cancer risk. The Breast Journal, 11(4), 266-272. doi:10.1111/j.1075-122x.2005.21693.x.

Mayer, E. L. (2013). Early and late long-term effects of adjuvant chemotherapy. American Society of Clinical Oncology - Educational Book, 9, 9-14.

McNeely, M. L., Campbell, K. L., Rowe, B. H., Klassen, T. P., Mackey, J. R., & Courneya, K. S. (2006). Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ, 175(1), 34-41. doi:10.1503/cmaj.051073.

McTiernan, A. (2005). Obesity and cancer: the risks, science, and potential management strategies. Oncology (Williston Park), 19(7), 871-881.

Melstrom, L. G., Melstrom, K. A., Jr., Ding, X. Z., & Adrian, T. E. (2007). Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia. Histology and Histopathology, 22(7), 805-814. doi:10.14670/HH-22.805.

Mishra, S. I., Scherer, R. W., Geigle, P. M., Berlanstein, D. R., Topaloglu, O., Gotay, C. C., & Snyder, C. (2012). Exercise interventions on health-related quality of life for cancer survivors. Cochrane Database Systematic Review, 8, CD007566. doi:10.1002/14651858.CD007566.pub2.

Newton, R. U., & Galvao, D. A. (2008). Exercise in prevention and management of cancer. Current Treatment Options in Oncology, 9(2-3), 135-146. doi:10.1007/s11864-008-0065-1.Palombaro, K. M., Black, J. D., Buchbinder, R., & Jette, D. U. (2013). Effectiveness of exercise for managing osteoporosis in women postmenopause. Physical Therapy, 93(8), 1021-1025. doi:10.2522/ptj.20110476.

Pfeiler, G., Konigsberg, R., Hadji, P., Fitzal, F., Maroske, M., Dressel-Ban, G., . . . & Dubsky, P. (2013). Impact of body mass index on estradiol depletion by aromatase inhibitors in postmenopausal women with early breast cancer. British Journal of Cancer, 109, 1522–1527. doi:10.1038/bjc.2013.499.

Pinkerton, J. V., & Thomas, S. (2014). Use of SERMs for treatment in postmenopausal women. The Journal of Steroid Biochemistry and Molecular Biology, 142, 142-154. doi:10.1016/j.jsbmb.2013.12.011.

Rietman, J. S., Dijkstra, P. U., Hoekstra, H. J., Eisma, W. H., Szabo, B. G., Groothoff, J. W., & Geertzen, J. H. (2003). Late morbidity after treatment of breast cancer in relation to daily activities and quality of life: a systematic review. European Journal of Surgical Oncology, 29(3), 229-238.

Sagen, A., Karesen, R., & Risberg, M. A. (2009). Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randomized controlled trial with two years follow-up. Acta Oncologica, 48(8), 1102-1110. doi:10.3109/02841860903061683.

Sanchez Varela, V., Zhou, E. S., & Bober, S. L. (2013). Management of sexual problems in cancer patients and survivors. Current Problems in Cancer, 37(6), 319-352. doi:10.1016/j.currproblcancer.2013.10.009.

Sasso, J. P., Eves, N. D., Christensen, J. F., Koelwyn, G. J., Scott, J., & Jones, L. W. (2015). A framework for prescription in exercise-oncology research. Journal of Cachexia, Sarcopenia and Muscle, 6(2), 115-124. doi:10.1002/jcsm.12042.

Saylor, P. J., Keating, N. L., & Smith, M. R. (2009). Prostate cancer survivorship: prevention and treatment of the adverse effects of androgen deprivation therapy. Journal of General Internal Medicine, 24 (Suppl 2), S389-394. doi:10.1007/s11606-009-0968-y.

Schmitz, K. H., Ahmed, R. L., & Yee, D. (2002). Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women. Cancer Epidemiology and Prevention Biomarkers, 11(12), 1597-1604.

Schmitz, K. H., Courneya, K. S., Matthews, C., Demark-Wahnefried, W., Galvao, D. A., Pinto, B. M., . . . & Schwartz, A. L. (2010). American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Medicine & Science in Sports & Exercise, 42(7), 1409-1426. doi:10.1249/MSS.0b013e3181e0c112.

SEOM. (2018). Las cifras del cáncer en España 2018.Obtenido de: https://www.seom.org/seomcms/images/stories/recursos/Las_Cifras_del_cancer_en_Espana2018.pdf: Spanish Society of Medical Oncology.

Short, C. E., James, E. L., Stacey, F., & Plotnikoff, R. C. (2013). A qualitative synthesis of trials promoting physical activity behaviour change among post-treatment breast cancer survivors. Journal of Cancer Survivorship, 7(4), 570–581. doi:10.1007/s11764-013-0296-4.

Travier, N., Velthuis, M. J., Steins Bisschop, C. N., van den Buijs, B., Monninkhof, E. M., Backx, F., . . . & May, A. M. (2015). Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial. BMC Medicine, 13, 121. doi:10.1186/s12916-015-0362-z.

Society AC. American Government. Retrieved from: http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-chemotherapy

World Cancer Research Fund, & American Institute for Cancer Research (2007). Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective, 1. American Institute for Cancer Research. Retrieved from: http://www.aicr.org/assets/docs/pdf/reports/Second_Expert_Report.pdf.

WHO. (2010). Recomendaciones mundiales sobre actividad física para la salud. Suiza: World Health Organization.

Wisloff, U., Ellingsen, O., & Kemi, O. J. (2009). High-intensity interval training to maximize cardiac benefits of exercise training? Exercise and Sport Sciences Reviews, 37(3), 139-146. doi:10.1097/JES.0b013e3181aa65fc.

Wiwanitkit, S., & Wiwanitkit, V. (2013). Postmenopausal osteoporosis, breast cancer, and aromatase inhibitor. Revista da Associação Médica Brasileira, 59(3), 217. doi:10.1016/j.ramb.2012.12.008.

Xie, Y., Collins, W. J., Audeh, M. W., Shiao, S. L., Gottlieb, R. A., Goodman, M. T., . . . & Mehta, P. K. (2015). Breast Cancer Survivorship and Cardiovascular Disease: Emerging Approaches in Cardio-Oncology. Current Treatment Options in Cardiovascular Medicine, 17(12), 60. doi:10.1007/s11936-015-0421-y.


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